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KMID : 0383820080650060464
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Tuberculosis and Respiratory Diseases
2008 Volume.65 No. 6 p.464 ~ p.470
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Presumptive Role of Neutrophilic Oxidative Stress in Oxygen-induced Acute Lung Injury in Rats
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Moon Yong-Suk
Lee Young-Man
Kim Ji-Hye
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Abstract
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Background: This study examined the role of neutrophilc oxidative stress in an O2-induced acute lung injury (ALI).
Methods: For 48 h, experimental rats were exposed to pure oxygen (normobaric hyperoxia) in a plastic cage.
Forty-eight hours after O2 breathing, the rats were sacrificed and the parameters for ALI associated with neutrophilic
oxidative stress were assessed
Results: Normobaric pure oxygen induced ALI, which was quite similar to ARDS. The O2-induced neutrophilic
oxidative stress was identified by confirming of the increase in lung myeloperoxidase, BAL neutrophils,
malondialdehyde (MDA), cytosolic phospholipase A2 (cPLA2) activity in the lung, histological changes and BAL
cytospin morphology.
Conclusion: In part, ALI-caused by oxygen is affected by neutrophils especially by the generation of free radicals.
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KEYWORD
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Acute Lung injury, O2 toxicity, Neutrophils
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